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WWC1 Mouse anti-Human, Clone: OTI1H8, lyophilized, TrueMAB™
SDP

Catalog No. 501665637
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100 μg
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Catalog No. Quantity
50-166-5637 100 μg
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Catalog No. 50-166-5637 Supplier OriGene Supplier No. CF801568
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Description

Mouse Monoclonal Antibody

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

WWC1 (Protein KIBRA) is a probable regulator of the Hippo/SWH signaling pathway. This pathway plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. WWC1, along with NF2, can synergistically induce the phosphorylation of LATS1 and LATS2. It acts as a transcriptional coactivator of ESR1 - which plays an essential role in DYNLL1-mediated ESR1 transactivation. WWC1 also functions as a regulatior of collagen-stimulated activation of the ERK/MAPK cascade.

Specifications

Antigen WWC1
Applications Western Blot
Classification Monoclonal
Clone OTI1H8
Conjugate Unconjugated
Formulation PBS with 8% trehalose and no preservative; pH 7.3
Gene WWC1
Gene Accession No. Q8IX03
Gene Alias HBEBP3, HBEBP36, KIBRA, MEMRYQTL, PPP1R168
Gene Symbols WWC1
Host Species Mouse
Immunogen Full length human recombit protein of human WWC1 produced in HEK293T cell.
Purification Method Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23286
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG2a
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