Invitrogen™ WWOX Monoclonal Antibody (3D10)

Catalog No.	Quantity
PIMA549188	100 μg

Catalog No. PIMA549188 Supplier Invitrogen™ Supplier No. MA549188

Description

Mouse Monoclonal Antibody

Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL. Positive Control - WB: human placenta tissue, human T-47D whole cell, human HepG2 whole cell, human U-87MG whole cell, human A549 whole cell, human Hela whole cell, human PC-3 whole cell, human Caco-2 whole cell, rat testicular tissue, rat brain tissue, rat liver tissue, mouse testicular tissue, mouse brain tissue, mouse liver tissue, mouse NIH/3T3 whole cell. IHC: human mammary cancer tissue, human ovarian cancer tissue, rat testis tissue, mouse testis tissue. ICC/IF: A431 cell. Flow: U20S cell. Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism. The encoded protein is more than 90% identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein. In addition, there is evidence that this gene behaves as a suppressor of tumor growth. Alternative splicing of this gene generates transcript variants that encode different isoforms.

Specifications

• Antigen: WWOX
• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Monoclonal
• Clone: 3D10
• Concentration: 500 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 4mg trehalose and 0.05mg sodium azide
• Gene: Wwox
• Gene Accession No.: Q91WL8, Q9NZC7
• Gene Alias: 5330426P09Rik; 9030416C10Rik; D16S432E; EIEE28; FOR; FRA16D; Fragile site FRA16D oxidoreductase; HHCMA56; PRO0128; SCAR12; SDR41C1; Short chain dehydrogenase/reductase family 41C member 1; short chain dehydrogenase/reductase family 41C, member 1; WOX1; WW domain containing oxidoreductase; WW domain-containing oxidoreductase; WW domain-containing protein WWOX; WW-domain oxidoreductase; Wwox
• Gene Symbols: Wwox
• Host Species: Mouse
• Immunogen: E. coli-derived human WWOX recombinant protein (Position: M1-D245).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 292041, 51741, 80707
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG1