Invitrogen™ WWOX Polyclonal Antibody

Catalog No.	Quantity
PIPA580233	100 μg

Catalog No. PIPA580233 Supplier Invitrogen™ Supplier No. PA580233

Description

Rabbit Polyclonal Antibody

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: human COLO320 whole cell, human HepG2 whole cell, human Jurkat whole cell, human 293T whole cell, human K562 whole cell, human A549 whole cell, human PC-3 whole cell, human Hela whole cell, rat testis tissue, rat kidney tissue, rat brain tissue, rat PC-12 whole cell, mouse testis tissue, mouse kidney tissue, mouse brain tissue, mouse NIH/3T3 whole cell. IHC: mouse brain tissue, rat brain tissue, rat testis tissue, human prostatic cancer tissue. Flow: U20S cell. ICC/IF: A549 cells.

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism. The encoded protein is more than 90% identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein. In addition, there is evidence that this gene behaves as a suppressor of tumor growth. Alternative splicing of this gene generates transcript variants that encode different isoforms.

Specifications

• Antigen: WWOX
• Applications: ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 500 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 4mg trehalose and 0.05mg sodium azide
• Gene: Wwox
• Gene Accession No.: Q91WL8, Q9NZC7
• Gene Alias: 5330426P09Rik; 9030416C10Rik; D16S432E; EIEE28; FOR; FRA16D; Fragile site FRA16D oxidoreductase; HHCMA56; PRO0128; SCAR12; SDR41C1; Short chain dehydrogenase/reductase family 41C member 1; short chain dehydrogenase/reductase family 41C, member 1; WOX1; WW domain containing oxidoreductase; WW domain-containing oxidoreductase; WW domain-containing protein WWOX; WW-domain oxidoreductase; Wwox
• Gene Symbols: Wwox
• Host Species: Rabbit
• Immunogen: E. coli-derived human WWOX recombinant protein (Position: M1-D245).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 292041, 51741, 80707
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov