Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Protein Analysis Reagents
  4. Bioactive Small Molecules
  5. Tocris Bioscience™ WZ 4002

Tocris Bioscience™ WZ 4002
GREENER_CHOICE

Catalog No. 629010
Change view
Click to view available options
Quantity:
10 mg
50 mg
Catalog No. Quantity
62-901-0 10 mg
62-905-0 50 mg
2 options
This item is not returnable. View return policy

Catalog No. 62-901-0

Supplier: Tocris Bioscience™ 6290/10

Only null left
Add to Cart
Add to Cart
This item is not returnable. View return policy

Description

Potent mutant-selective EGFR inhibitor

WZ 4002 is a potent irreversible mutant selective EGFR tyrosine kinase inhibitor. It blocks ATP-dependent autophosphorylation of EGFR carrying the T790M or L858R mutation (IC50 = 8 nM). WZ 4002 exhibits selectivity for mutant EGFR over wild-type. In mice bearing T790M mutant lung cancer cell lines WZ 4002 inhibits EGFR, AKT and ERK1/2 phosphorylation and results in significant tumor regression.

Specifications

Chemical Name or Material N-[3-[[5-Chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]-2-propenamide
CAS 1213269-23-8
Quantity 10 mg
Target EGF Receptor Inhibitors
Molecular Formula C25H27ClN6O3
Purity 0.98
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.