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  5. Tocris Bioscience™ WZ 4002

Tocris Bioscience™ WZ 4002
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Catalog No. 629050
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62-905-0 50 mg
62-901-0 10 mg
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Catalog No. 62-905-0 Supplier Tocris Bioscience™ Supplier No. 6290/50
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Description

Potent mutant-selective EGFR inhibitor

WZ 4002 is a potent irreversible mutant selective EGFR tyrosine kinase inhibitor. It blocks ATP-dependent autophosphorylation of EGFR carrying the T790M or L858R mutation (IC50 = 8 nM). WZ 4002 exhibits selectivity for mutant EGFR over wild-type. In mice bearing T790M mutant lung cancer cell lines WZ 4002 inhibits EGFR, AKT and ERK1/2 phosphorylation and results in significant tumor regression.

Specifications

Chemical Name or Material N-[3-[[5-Chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]-2-propenamide
CAS 1213269-23-8
Quantity 50 mg
Target EGF Receptor Inhibitors
Molecular Formula C25H27ClN6O3
Purity 0.98
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