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  5. Tocris Bioscience™ WZB 117

Tocris Bioscience™ WZB 117
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Catalog No. 61435 Shop All R&D Systems Products
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Catalog No. Quantity
61-435 5 mg
61-432-5 25 mg
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Catalog No. 61-435 Supplier Tocris Bioscience™ Supplier No. 6143/5
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Description

GLUT inhibitor

WZB 117 is a GLUT inhibitor (Ki(app) values are 0.2, 10 and 10 μM for GLUT4, GLUT1 and GLUT3, respectively). Competitive inhibitor of net glucose uptake but a noncompetitive inhibitor of sugar efflux from cells. Inhibits passive sugar transport in human erythrocytes and cancer cell lines. Attenuates erythrocyte 3-O-metylglucose (3MG) uptake in vitro (Ki = 6 μM). Suppresses tumor growth in a nude mouse model.

Specifications

Chemical Name or Material 3-Fluoro-1,2-phenylene bis(3-hydroxybenzoate)
CAS 1223397-11-2
Assay Percent Range >98%
Quantity 5 mg
Molecular Formula C20H13FO6
Formula Weight Observed MW: 368.31
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