Invitrogen™ XAF1 Polyclonal Antibody

Catalog No.	Quantity
PIPA520038	100 μg

Catalog No. PIPA520038 Supplier Invitrogen™ Supplier No. PA520038

Description

Rabbit Polyclonal Antibody

In Western blot applications, this antibody detects a band at ~32kDa. A suggested positive control is human spleen tissue lysate. PA5-20038 can be used with blocking peptide PEP-0157.

The inhibitors of apoptosis (IAP) proteins prevent cell death both in vitro and in vivo by virtue of inhibition of distinct caspases. The X-linked Inhibitor of Apoptosis, XIAP, is a key member of the IAP family of proteins. The caspase inhibiting activity of XIAP is negatively regulated by at least two XIAP-interacting proteins, XIAP-associated factor 1 (XAF1) and Smac/DIABLO. XAF1 binds to XIAP and antagonizes caspase inhibitory activities of XIAP. Expression of XAF1 triggers a redistribution of XIAP from the cytosol to the nucleus. XAF1 is ubiquitously expressed in normal tissues, but is present at low or undetectable levels in many different cancer cell lines.

Specifications

• Antigen: XAF1
• Applications: Immunohistochemistry, Western Blot
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.02% sodium azide
• Gene: XAF1
• Gene Accession No.: Q5NBU8, Q6GPH4
• Gene Alias: BIRC4 binding protein; BIRC4-binding protein; Birc4bp; F-box protein 39; Fbox39; HSXIAPAF1; novel TRAF-type zinc finger protein; XAF1; XIAP associated factor 1; XIAP associated factor-1; Xiapaf1; XIAP-associated factor 1
• Gene Symbols: XAF1
• Host Species: Rabbit
• Immunogen: A synthetic peptide corresponding to amino acids at the C-terminus of human XAF-1.
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 327959, 54739
• Target Species: Human, Mouse
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG