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Invitrogen™ XAF1 Polyclonal Antibody
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Catalog No. PIPA520090
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100 μg
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Catalog No. Quantity
PIPA520090 100 μg
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Catalog No. PIPA520090 Supplier Invitrogen™ Supplier No. PA520090
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Description

Rabbit Polyclonal Antibody

This antibody recognizes multiple isoforms of XAF-1. In Western blot applications, a doublet is detected at ~30kDa. A suggested positive control is human spleen tissue lysate. PA5-20090 can be used with blocking peptide PEP-0208.

The inhibitors of apoptosis (IAP) proteins prevent cell death both in vitro and in vivo by virtue of inhibition of distinct caspases. The X-linked Inhibitor of Apoptosis, XIAP, is a key member of the IAP family of proteins. The caspase inhibiting activity of XIAP is negatively regulated by at least two XIAP-interacting proteins, XIAP-associated factor 1 (XAF1) and Smac/DIABLO. XAF1 binds to XIAP and antagonizes caspase inhibitory activities of XIAP. Expression of XAF1 triggers a redistribution of XIAP from the cytosol to the nucleus. XAF1 is ubiquitously expressed in normal tissues, but is present at low or undetectable levels in many different cancer cell lines.
TRUSTED_SUSTAINABILITY

Specifications

Antigen XAF1
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene XAF1
Gene Accession No. Q6GPH4
Gene Alias BIRC4 binding protein; BIRC4-binding protein; Birc4bp; F-box protein 39; Fbox39; HSXIAPAF1; novel TRAF-type zinc finger protein; XAF1; XIAP associated factor 1; XIAP associated factor-1; Xiapaf1; XIAP-associated factor 1
Gene Symbols XAF1
Host Species Rabbit
Immunogen A synthetic peptide corresponding to 16 amino acids near the middle of human XAF-1.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 54739
Target Species Human
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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