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XAF1 Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501982603
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100 μL
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Catalog No. Quantity
50-198-2603 100 μL
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Catalog No. 50-198-2603 Supplier Bioss Supplier No. BS1308R
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Description

Rabbit Polyclonal Antibody

The inhibitors of apoptosis (IAP) proteins prevent cell death both in vitro and in vivo by virtue of inhibition of distinct caspases. The X-linked Inhibitor of Apoptosis, XIAP, is a key member of the IAP family of proteins. The caspase inhibiting activity of XIAP is negatively regulated by at least two XIAP-interacting proteins, XIAP-associated factor 1 (XAF1) and Smac/DIABLO. XAF1 binds to XIAP and antagonizes caspase inhibitory activities of XIAP. Expression of XAF1 triggers a redistribution of XIAP from the cytosol to the nucleus. XAF1 is ubiquitously expressed in normal tissues, but is present at low or undetectable levels in many different cancer cell lines.

Specifications

Antigen XAF1
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene XAF1
Gene Accession No. Q6GPH4
Gene Alias BIRC4 binding protein; BIRC4-binding protein; Birc4bp; F-box protein 39; Fbox39; HSXIAPAF1; novel TRAF-type zinc finger protein; Xaf1; XIAP associated factor 1; XIAPAF1; XIAP-associated factor 1
Gene Symbols XAF1
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from mouse XAF1.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 54739
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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