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Tocris Bioscience™ XAV 939
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Catalog No. 374850
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Catalog No. Quantity
37-485-0 50 mg
37-481-0 10 mg
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Catalog No. 37-485-0 Supplier Tocris Bioscience™ Supplier No. 3748/50
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Description

Potent tankyrase inhibitor

XAV 939 is a potent tankyrase (TNKS) inhibitor (IC50 values are 4 and 11 nM for TNKS2 and TNKS1 respectively). Antagonizes Wnt signaling via stimulation of β-catenin degradation and stabilization of axin. XAV 939 inhibits proliferation of the β-catenin-dependent colon carcinoma cell line DLD-1. Promotes cardiomyocyte differentiation in mesoderm progenitor cells. Also used in neuronal differentiation protocols.

XAV 939 synthesized to cGMP guidelines also available.

For more information about how XAV 939 may be used, see our protocol: Accelerated Induction of Cortical Neurons from hiPSCs

Chemical Identifiers

CAS 284028-89-3
Molecular Formula C14H11F3N2OS

Specifications

Quantity 50 mg
Formula Weight 312.31
Purity >98%
Molecular Weight (g/mol) 312.31
Chemical Name or Material XAV 939

Safety and Handling

Recommended Storage Store at Room Temperature
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