XBP1 Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-173-4250	Proteintech Group Inc 241681AP150UL	150 μL

Description

The XBP1 antibody (24168-1-AP) can detect both isoforms XBP1(U) and XBP1(S).

XBP1 encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5.

Specifications

• Antigen: XBP1
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse
• Gene Accession No.: O35426, P17861
• Gene ID (Entrez): 22433, 7494
• Immunogen: XBP1 Fusion Protein Ag21454
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: XBP1

• Concentration: 0.37 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: TREB5, X box binding protein 1, XBP 1, XBP1, XBP2
• Gene Symbols: XBP1
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody