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XIAP/BIRC4 Rabbit anti-Human, Polyclonal, Bioss

Rabbit Polyclonal Antibody
Supplier: Bioss BS1281R

Description
Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family including IAP, XIAP/ILP-1/MIHA, and Livin/KIAP that bind to and inhibits specific proteases. A novel member in the IAP protein family was recently identified and designated ILP-2 for IAP-like protein-2. ILP-2 has high homology to ILP-1, but is encoded by a distinct gene that is solely expressed in testis of tested normal human tissues. ILP-2, unlike ILP-1, has no inhibitory effect on Fas and TNF induced apoptosis, but potently inhibits apoptosis induced by overexpression of Bax or by coexpression of caspase-9 with Apaf-1. ILP-2 interacts with the processed caspase-9. These results suggest that ILP-2 is a novel IAP family member with restricted specificity for caspase-9.Specifications
XIAP/BIRC4 | |
Polyclonal | |
Unconjugated | |
BIRC8 | |
baculoviral IAP repeat containing 8; baculoviral IAP repeat-containing 8; baculoviral IAP repeat-containing protein 8; BIRC8; hILP2; IAP-like protein 2; ILP2; ILP-2; inhibitor of apoptosis-like protein 2; testis-specific inhibitor of apoptosis | |
Rabbit | |
Protein A | |
RUO | |
112401 | |
-20°C | |
Liquid |
Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot | |
1 μg/mL | |
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH | |
Q96P09 | |
BIRC8 | |
KLH conjugated synthetic peptide derived from mouse XIAP. | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
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