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  5. Tocris Bioscience™ XL 413 Hydrochloride

Tocris Bioscience™ XL 413 Hydrochloride
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Catalog No. 549350
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Catalog No. 549350 Supplier Tocris Bioscience™ Supplier No. 5493/50
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Description

Potent and selective Cdc7 inhibitor

XL 413 hydrochloride is a potent and selective Cdc7 inhibitor (IC50 = 3.4 nM). Exhibits >12-fold selectivity for Cdc7 over PIM-1 kinase and >30-fold selectivity over pMCM and CK2. Inhibits proliferation of Colo 205 cells in vitro and attenuates tumor growth of Colo 205 xenografts in mice. XL 413 also improves homology-directed repair (HDR) editing in hematopoietic stem cells (HSC).

Specifications

Chemical Name or Material 8-Chloro-2-(2S)-2-pyrrolidinylbenzofuro[3,2-d]pyrimidin-4(3H)-one hydrochloride
CAS 1169562-71-3
Quantity 50 mg
Solubility Soluble to 20mM in water
Molecular Formula C14H12ClN3O2.HCl
Formula Weight Observed MW: 326.18
Purity >99%

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