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Invitrogen™ XPA Monoclonal Antibody (5A2)
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Catalog No. PIMA121460
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100 μg
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Catalog No. Quantity
PIMA121460 100 μg
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Catalog No. PIMA121460 Supplier Invitrogen™ Supplier No. MA121460
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Description

Mouse Monoclonal Antibody

Positive controls of LS174T, MCF-7 cells or human tonsil suggested. Works on pure and partially purified protein but not on crude cell extract.

The XPA (xeroderma pigmentosumgroup A) protein specifically recognizes the UV-orchemically damaged DNA lesions, and triggers thenucleotide excision repair process. XPA binds to thereplication protein A (RPA) or the excision repaircross complementing 1 protein (ERCC 1). In the absence of nucleotide excision repair persisting (unrepaired) DNA lesions (adducts) may lead to the accumulation of gene mutations and ultimately to cancer. Xeroderma pigmentosum patients have a >2000 fold increased risk to develop skin cancer atsun-exposed areas.
TRUSTED_SUSTAINABILITY

Specifications

Antigen XPA
Applications Dot Blot, ELISA, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 5A2
Concentration 1.1 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene XPA
Gene Accession No. P23025
Gene Alias AI573865; DNA repair protein complementing XP-A cells; DNA repair protein complementing XP-A cells homolog; excision repair-controlling; mutant xeroderma pigmentosum complementation group A; xeroderma pigmentosum group A-complementing protein; Xeroderma pigmentosum group A-complementing protein homolog; xeroderma pigmentosum, complementation group A; XP1; XPA; XPA, DNA damage recognition and repair factor; Xpac
Gene Symbols XPA
Host Species Mouse
Immunogen Recombinant human XPA (Xeroderma Pigmentosum group A) protein.
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7507
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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