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XPF Monoclonal Antibody (OTI2A1), TrueMAB™, OriGene
SDP

Catalog No. 501674240
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50-167-4240 100 μL
50-254-0983 30 μL
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Catalog No. 50-167-4240 Supplier OriGene Supplier No. TA503314
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Description

Mouse Monoclonal Antibody

The structure specific ERCC 1 / XPF endonuclease complex is implicated in the repair of two distinct types of lesions in DNA: NER for UV induced lesions and bulky chemical adducts; and recombination repair of the very genotoxic interstrand cross links. NER mechanism involves dual incisions on both sides of the damage catalyzed by two nucleases. In mammalian cells, XPG cleaves 3′ of the DNA lesion while the ERCC1 / XPF complex makes the 5′ incision. ERCC1 / XPF probably plays a role in processing partially processed recombination intermediates.

Specifications

Antigen XPF
Applications Flow Cytometry, Immunocytochemistry, Immunofluorescence, Western Blot
Classification Monoclonal
Clone OTI2A1
Concentration 0.93 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene ERCC4
Gene Accession No. Q92889, Q9QZD4
Gene Alias ERCC11, FANCQ, RAD1, XFEPS, XPF
Gene Symbols Ercc4
Host Species Mouse
Immunogen Full length human recombit protein of human ERCC4 produced in HEK293 cell.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2072, 304719, 479842, 50505
Target Species Canine, Human, Mouse, Rat
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG2a
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