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Invitrogen™ XPF Polyclonal Antibody
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Catalog No. PIPA583797
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100 μL
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PIPA583797 100 μL
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Catalog No. PIPA583797 Supplier Invitrogen™ Supplier No. PA583797
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: SKPQPDAATA LAITADSETL PESEKYNPGP QDFLLKMPGV NAKNCRSLMH HVKNIAELAA LSQDELTSIL GNAANAKQLY DFIHTSFAEV VSKGKGK Highest antigen sequence indentity to the following orthologs: Mouse - 75%, Rat - 74%.

The structure specific ERCC 1 / XPF endonuclease complex is implicated in the repair of two distinct types of lesions in DNA: NER for UV induced lesions and bulky chemical adducts; and recombination repair of the very genotoxic interstrand cross links. NER mechanism involves dual incisions on both sides of the damage catalyzed by two nucleases. In mammalian cells, XPG cleaves 3' of the DNA lesion while the ERCC1 / XPF complex makes the 5' incision. ERCC1 / XPF probably plays a role in processing partially processed recombination intermediates.
TRUSTED_SUSTAINABILITY

Specifications

Antigen XPF
Applications Western Blot, Immunocytochemistry, Western Blot
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene ERCC4
Gene Accession No. Q92889
Gene Alias AI606920; DNA excision repair protein ERCC-4; DNA repair endonuclease subunit; DNA repair endonuclease XPF; DNA repair protein complementing XP-F cells; ERCC excision repair 4, endonuclease catalytic subunit; ERCC11; ERCC4; Ercc4 protein-like; excision repair cross-complementation group 4; excision repair cross-complementing rodent repair deficiency, complementation group 4; excision-repair, complementing defective, in Chinese hamster; FANCQ; RAD1; RGD1560340; Xeroderma pigmentosum group F-complementing protein; xeroderma pigmentosum, complementation group F; XFEPS; XPF
Gene Symbols ERCC4
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human ERCC4. Recombinant protein control fragment (Product #RP-104810).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2072
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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