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Invitrogen™ XPF Polyclonal Antibody
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Catalog No. PIPA5117118
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100 μL
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PIPA5117118 100 μL
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Catalog No. PIPA5117118 Supplier Invitrogen™ Supplier No. PA5117118
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Description

Rabbit Polyclonal Antibody

Positive Samples: U-251MG, HT-1080 Immunogen sequence: GYRREISSSP ESCPEEIKHE EFDVNLSSDA AFGILKEPLT IIHPLLGCSD PYALTRVLHE VEPRYVVLYD AELTFVRQLE IYRASRPGKP LRVYFLIYGG STEEQRYLTA LRKEKEAFEK LIREKASMVV PEEREGRDET NLDLVRGTAS ADVSTDTRKA GGQEQNGTQQ SIVVDMREFR SELPSLIHRR GIDIEPVTLE VGDYILTPEM CVERKSISDL IGSLNNGRLY SQCISMSRYY KRPVLLIEFD PSKPFSLTSR GALFQEISSN.

The structure specific ERCC 1 / XPF endonuclease complex is implicated in the repair of two distinct types of lesions in DNA: NER for UV induced lesions and bulky chemical adducts; and recombination repair of the very genotoxic interstrand cross links. NER mechanism involves dual incisions on both sides of the damage catalyzed by two nucleases. In mammalian cells, XPG cleaves 3' of the DNA lesion while the ERCC1 / XPF complex makes the 5' incision. ERCC1 / XPF probably plays a role in processing partially processed recombination intermediates.
TRUSTED_SUSTAINABILITY

Specifications

Antigen XPF
Applications ELISA, Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 1.49 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene ERCC4
Gene Accession No. Q92889, Q9QZD4
Gene Alias AI606920; DNA excision repair protein ERCC-4; DNA repair endonuclease subunit; DNA repair endonuclease XPF; DNA repair protein complementing XP-F cells; ERCC excision repair 4, endonuclease catalytic subunit; ERCC11; ERCC4; Ercc4 protein-like; excision repair cross-complementation group 4; excision repair cross-complementing rodent repair deficiency, complementation group 4; excision-repair, complementing defective, in Chinese hamster; FANCQ; RAD1; RGD1560340; Xeroderma pigmentosum group F-complementing protein; xeroderma pigmentosum, complementation group F; XFEPS; XPF
Gene Symbols ERCC4
Host Species Rabbit
Immunogen Synthetic peptide.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2072, 304719, 50505
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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