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Invitrogen™ XPNPEP3 Polyclonal Antibody
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Catalog No. PIPA551402
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100 μL
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Catalog No. Quantity
PIPA551402 100 μL
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Catalog No. PIPA551402 Supplier Invitrogen™ Supplier No. PA551402
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: THPHLLRPGE VTPGLSQVEY ALRRHKLMSL IQKEAQGQSG TDQTVVVLSN PTYYMSNDIP YTFHQDNNFL YLCGFQEPDS ILVLQSLPGK QLPSHKAILF VPRRDPSREL WDGPRSGTDG AIALTGVDEA YTLEEFQHLL PKMKAETNMV WYDWMRPSHA QLHSDYMQ Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 90%.

XPNPEP3, also known as X-Prolyl Aminopeptidase 3, is a gene located on chromosome 22q that encodes an enzyme involved in the processing of mitochondrial matrix proteins. The enzyme is classified under the M24B subfamily of metallopeptidases, which specifically remove the N-terminal amino acid from oligopeptides where the penultimate residue is proline. XPNPEP3 is implicated in conditions such as cystic kidney disease and participates in TNF-TNFR2 cellular signaling pathways. Its yeast and plant homologs, like Icp55, perform similar functions by stabilizing proteins after import into the mitochondrial matrix. Mutations in XPNPEP3 are associated with defects in ciliary structure and function, contributing to the phenotypic spectrum seen in nephronophthisis-related ciliopathies (NPHP-RCs). The crystal structure of XPNPEP3 has been resolved at 1.65 A resolution, revealing its interaction with inhibitors such as apstatin. Furthermore, XPNPEP3 is identified as a transcriptional target of the canonical Wnt/beta-catenin signaling pathway, with elevated transcript levels observed in tumors exhibiting activated Wnt signaling.
TRUSTED_SUSTAINABILITY

Specifications

Antigen XPNPEP3
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene XPNPEP3
Gene Accession No. B5DEQ3, Q9NQH7
Gene Alias Aminopeptidase P3; APP3; E430012M05Rik; ICP55; Intermediate Cleaving Peptidase 55; LOW QUALITY PROTEIN: xaa-Pro aminopeptidase 3; NPHPL1; probable Xaa-Pro aminopeptidase 3; putative Xaa-Pro aminopeptidase 3; Xaa-Pro aminopeptidase 3; xaa-Pro aminopeptidase 3; probable Xaa-Pro aminopeptidase 3; XPNPEP3; X-Pro aminopeptidase 3; X-prolyl aminopeptidase (aminopeptidase P) 3, putative; X-prolyl aminopeptidase 3; X-prolyl aminopeptidase 3, mitochondrial; zgc:76905; zgc:76905 protein
Gene Symbols XPNPEP3
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human XPNPEP3. Recombinant protein control fragment (Product #RP-91390).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 63929, 685823
Target Species Human, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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