Invitrogen™ XRCC1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA529359

Catalog No. PIPA529359

Description

Recommended positive controls: 293T, A431. Predicted reactivity: Mouse (90%), Rat (90%), Dog (90%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

XRCC1 (X-ray cross complementing factor-1) is involved in DNA base excision repair. XRCC1 is a 70 kDa protein that has been shown to be physically associated with other DNA repair enzymes, including poly (ADP-ribose) polymerase (PARP), DNA Ligase III and DNA polymerase beta. XRCC1 contains a BRCT domain (for BRCA1 carboxyl terminus) which was originally found in the tumor suppressor protein BRCA1. Recently, the BRCT domain has been shown to mediate the protein-protein interaction of XRCC1 and DNA ligase III-alpha.

Specifications

• Antigen: XRCC1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: XRCC1
• Gene Alias: DNA repair protein XRCC1; RCC; X-ray repair complementing defective repair in Chinese hamster cells 1; X-ray repair cross complementing 1; x-ray repair cross-complementing group 1 protein; X-ray repair cross-complementing protein 1; XRCC1; Xrcc-1
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 7515, 84495
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.73 mg/mL
• Formulation: 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: P18887, Q9ESZ0
• Gene Symbols: XRCC1
• Immunogen: Recombinant fragment corresponding to a region within amino acids 1 and 281 of Human XRCC1.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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