Invitrogen™ XRCC4 Monoclonal Antibody (OTI4H9)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA524983

Catalog No. PIMA524983

Description

XRCC4 Monoclonal Antibody for Western Blot, ICC/IF, IHC (P)

The x-ray repair cross-complementing (XRCC) proteins are responsible for efficiently repairing and maintaining genetic stability following DNA base damage. These genes share sequence similarity with the yeast DNA repair protein Rad51. XRCC4 is an accessory factor of DNA ligase IV that preferentially binds DNA with nicks or broken ends. XRCC4 binds to DNA ligase IV and enhances its joining activity, and it is also involved in V(D)J recombination. Any defect in one of the known components of the DNA repair/V(D)J recombination machinery (Ku-70, Ku-80, DNA-PKCS, XRCC4 and DNA ligase IV) leads to abortion of the V(D)J rearrangement process and early block in both T and B cell maturation.

Specifications

• Antigen: XRCC4
• Classification: Monoclonal
• Concentration: 1.0 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q13426, Q924T3
• Gene Symbols: XRCC4
• Immunogen: Full-length protein expressed in 293T cell transfected with human XRCC4 expression vector.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Clone: OTI4H9
• Conjugate: Unconjugated
• Gene: XRCC4
• Gene Alias: 2310057B22Rik; AW413319; AW545101; DNA repair protein XRCC4; SSMED; X-ray repair complementing defective repair in Chinese hamster cells 4; X-ray repair cross complementing 4; X-ray repair cross complementing protein 4; X-ray repair cross-complementing protein 4; XRCC4
• Host Species: Mouse
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 108138, 7518
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid