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Invitrogen™ XRCC4 Monoclonal Antibody (OTI4H9)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA524983

Catalog No. PIMA524983


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Description

Description

XRCC4 Monoclonal Antibody for Western Blot, ICC/IF, IHC (P)

The x-ray repair cross-complementing (XRCC) proteins are responsible for efficiently repairing and maintaining genetic stability following DNA base damage. These genes share sequence similarity with the yeast DNA repair protein Rad51. XRCC4 is an accessory factor of DNA ligase IV that preferentially binds DNA with nicks or broken ends. XRCC4 binds to DNA ligase IV and enhances its joining activity, and it is also involved in V(D)J recombination. Any defect in one of the known components of the DNA repair/V(D)J recombination machinery (Ku-70, Ku-80, DNA-PKCS, XRCC4 and DNA ligase IV) leads to abortion of the V(D)J rearrangement process and early block in both T and B cell maturation.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

XRCC4
Monoclonal
1.0 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q13426, Q924T3
XRCC4
Full-length protein expressed in 293T cell transfected with human XRCC4 expression vector.
100 μL
Primary
Human, Mouse
Antibody
IgG1
Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
OTI4H9
Unconjugated
XRCC4
2310057B22Rik; AW413319; AW545101; DNA repair protein XRCC4; SSMED; X-ray repair complementing defective repair in Chinese hamster cells 4; X-ray repair cross complementing 4; X-ray repair cross complementing protein 4; X-ray repair cross-complementing protein 4; XRCC4
Mouse
Affinity chromatography
RUO
108138, 7518
-20°C, Avoid Freeze/Thaw Cycles
Liquid
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