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Invitrogen™ XRCC4 Polyclonal Antibody
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Catalog No. PIPA582264
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100 μL
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PIPA582264 100 μL
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Catalog No. PIPA582264 Supplier Invitrogen™ Supplier No. PA582264
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: KCVSAKEALE TDLYKRFILV LNEKKTKIRS LHNKLLNAAQ EREKDIKQEG ETAICSEMTA DRDPVYDEST DEESENQTDL SGLASAAVSK DDSIISSLDV TDIAPSRKRR QRMQRNLGTE PKMAPQENQL QEK Highest antigen sequence indentity to the following orthologs: Mouse - 67%, Rat - 63%.

The x-ray repair cross-complementing (XRCC) proteins are responsible for efficiently repairing and maintaining genetic stability following DNA base damage. These genes share sequence similarity with the yeast DNA repair protein Rad51. XRCC4 is an accessory factor of DNA ligase IV that preferentially binds DNA with nicks or broken ends. XRCC4 binds to DNA ligase IV and enhances its joining activity, and it is also involved in V(D)J recombination. Any defect in one of the known components of the DNA repair/V(D)J recombination machinery (Ku-70, Ku-80, DNA-PKCS, XRCC4 and DNA ligase IV) leads to abortion of the V(D)J rearrangement process and early block in both T and B cell maturation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen XRCC4
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene XRCC4
Gene Accession No. Q13426
Gene Alias 2310057B22Rik; AW413319; AW545101; DNA repair protein XRCC4; SSMED; X-ray repair complementing defective repair in Chinese hamster cells 4; X-ray repair cross complementing 4; X-ray repair cross complementing protein 4; X-ray repair cross-complementing protein 4; XRCC4
Gene Symbols XRCC4
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human XRCC4. Recombinant protein control fragment (Product #RP-89487).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7518
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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