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Invitrogen™ XRCC4 Polyclonal Antibody
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Catalog No. PIPA5116138
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100 μL
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PIPA5116138 100 μL
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Catalog No. PIPA5116138 Supplier Invitrogen™ Supplier No. PA5116138
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total XRCC4.

The x-ray repair cross-complementing (XRCC) proteins are responsible for efficiently repairing and maintaining genetic stability following DNA base damage. These genes share sequence similarity with the yeast DNA repair protein Rad51. XRCC4 is an accessory factor of DNA ligase IV that preferentially binds DNA with nicks or broken ends. XRCC4 binds to DNA ligase IV and enhances its joining activity, and it is also involved in V(D)J recombination. Any defect in one of the known components of the DNA repair/V(D)J recombination machinery (Ku-70, Ku-80, DNA-PKCS, XRCC4 and DNA ligase IV) leads to abortion of the V(D)J rearrangement process and early block in both T and B cell maturation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen XRCC4
Applications Immunohistochemistry (PFA fixed), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide
Gene XRCC4
Gene Accession No. Q13426, Q924T3
Gene Alias 2310057B22Rik; AW413319; AW545101; DNA repair protein XRCC4; SSMED; X-ray repair complementing defective repair in Chinese hamster cells 4; X-ray repair cross complementing 4; X-ray repair cross complementing protein 4; X-ray repair cross-complementing protein 4; XRCC4
Gene Symbols XRCC4
Host Species Rabbit
Immunogen A synthesized peptide derived from human XRCC4(Accession Q13426), corresponding to amino acid residues D234-P284.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 108138, 309995, 7518
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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