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Invitrogen™ YAP1 Polyclonal Antibody
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Catalog No. PIPA5120528
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100 μL
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PIPA5120528 100 μL
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Catalog No. PIPA5120528 Supplier Invitrogen™ Supplier No. PA5120528
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Description

Rabbit Polyclonal Antibody

Positive test controls include: A-549, DU145, NIH/3T3, HeLa, Mouse lung. The target is usually found in the following locations: Cytoplasm, Nucleus. Immunogen sequence: QGGVLGGGSS NQQQQIQLQQ LQMEKERLRL KQQELFRQAI RNINPSTANA PKCQELALRS QLPTLEQDGG TPNAVSSPGM SQELRTMTTN SSDPFLNSGT YHSRDESTDS GLSMSSYSIP RTPDDFLNSV DEMDTGDTIS QSTLPSQQSR FPDYLEALPG TNVDLGTLEG DAMNIEGEEL MPSLQEALSS EILDVESVLA ATKLDKESFL TWL.

YAP (Yes-Associated Protein) is a founding member of the WW domain family of proteins, transcriptional co-activator and oncogene. Its gene is transcriptionally activated in squamous cell carcinoma cells. YAP can act both as a coactivator and corepressor and is the critical downstream regulatory target in the Hippo signaling pathway. The Hippo signaling pathway plays a pivotal role in organ size control and tumour suppression by restricting proliferation and promoting apoptosis. Also plays key roles in tissue tension, 3D tissue shape, cell proliferation, cell death, and cell migration. Mutations in the IRF5 gene results in coloboma.
TRUSTED_SUSTAINABILITY

Specifications

Antigen YAP1
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1.38 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene YAP1
Gene Accession No. P46937, P46938, Q2EJA0
Gene Alias 65 kDa Yes-associated protein; AI325207; cb194; CH211-181P1.5-001; COB1; Protein yorkie homolog; sb:cb194; si:ch211-181p1.5; si:dkey-3b8.3; transcriptional coactivator YAP1; wu:fc18c04; yap; Yap1; YAP2; Yap65; Yes associated protein 1; Yes1 associated transcriptional regulator; yes-associated protein 1; yes-associated protein 2; yes-associated protein YAP65 homolog; yes-associated protein, 65 kDa; Yki; Yorkie; yorkie homolog; zgc:158380; zYAP
Gene Symbols YAP1
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 276-488 of mouse YAP1 (NP_0011646181).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10413, 22601, 363014
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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