YB1 Rabbit anti-Human, Mouse, Polyclonal, Bethyl Laboratories
Rabbit Polyclonal Antibody
Supplier: Bethyl Laboratories, Inc A303231A
The recommended shelf life for this product is 1 year from date of receipt. Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections. Based on 100% sequence identity, this antibody is predicted to react with Rat, Bovine and RabbitYBX1 binds to splice sites in pre-mRNA and regulates splice site selection. This protein binds and stabilizes cytoplasmic mRNA and contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors. It binds to promoters that contain a Y-box (5′-CTGATTGGCCAA-3′), such as HLA class II genes. It regulates the transcription of numerous genes and promotes separation of DNA strands that contain mismatches or are modified by cisplatin. It has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro), and it may play a role in DNA repair.
|Nuclease-sensitive element-binding protein 1; Y-box-binding protein 1; Y-box transcription factor; YB-1; CCAAT-binding; transcription factor I subunit A; CBF-A; Enhancer factor I subunit A; EFI-A; DNA-binding protein B; DBPB; YBX1; NSEP1; YB1|
|Antigen affinity chromatography|
|Immunohistochemistry, Immunoprecipitation, Western Blot|
|TBS with 0.1% BSA and 0.09% sodium azide|
|Between 274 and 324|
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