Invitrogen™ YBX1 Recombinant Rabbit Monoclonal Antibody (9J7M4)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA542819

Catalog No. PIMA542819

Description

Positive test controls include: Mouse testis, Rat heart, HeLa. The target is usually found in the following locations: Cytoplasm, Cytoplasmic granule, Nucleus, Secreted. Immunogen sequence: GAGEQGRPVR QNMYRGYRPR FRRGPPRQRQ PREDGNEEDK ENQGDETQGQ QPPQRRYRRN FNYRRRRPEN PKPQDGKETK AADPPAENSS APEAEQGGAE.

YBX1 binds to splice sites in pre-mRNA and regulates splice site selection. This protein binds and stabilizes cytoplasmic mRNA and contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors. It binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as HLA class II genes. It regulates the transcription of numerous genes and promotes separation of DNA strands that contain mismatches or are modified by cisplatin. It has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro), and it may play a role in DNA repair.

Specifications

• Antigen: YBX1
• Classification: Recombinant Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P62960, P62961, P67809
• Gene Symbols: YBX1
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 225-324 of human YB-1/YBX1 (P67809).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
• Clone: 9J7M4
• Conjugate: Unconjugated
• Gene: YBX1
• Gene Alias: 1700102N10Rik; BP8; BP-8; Byb1; C79409; Cbfa; CBF-A; CCAAT-binding; CCAAT-binding transcription factor 1 subunit A; CCAAT-binding transcription factor I subunit A; CSDA2; CSDB; dbpB; DNA binding protein B; DNA-binding protein B; EF1A; EFI-A; enhancer factor 1 alpha; enhancer factor 1 subunit A; enhancer factor I subunit A; major histocompatibility complex, class II, Y box-binding protein I; MDR NF1; MDR-NF1; MGC104858; MGC110976; MGC117250; Msy1; Msy-1; mYB-1a; Nsep1; NSEP-1; nuclease sensitive element binding protein 1; nuclease-sensitive element-binding protein 1; Y box binding protein 1; Y box protein 1; Y box transcription factor; YB1; YB-1; Y-box binding protein 1; Y-box transcription factor; Y-box-binding protein 1; YBX1
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 22608, 4904, 500538
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid