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Tocris Bioscience™ YKL 5-124
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Catalog No. 71575
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71-575 5 mg
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Catalog No. 71-575 Supplier Tocris Bioscience™ Supplier No. 7157/5
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Description

Potent and selective CDK7 inhibitor; induces cell cycle arrest

YKL-5-124 is a potent and selective CDK7/Mat1/CycH and cyclin dependent kinase (CDK7) inhibitor (IC50 values = 9.7 nM and 53.5 nM, respectively). YKL-5-124 shows 100-fold selectivity over CDK9 and CDK2. YKL-5-124 induces cell cycle arrest at the G1/S transition, inhibits E2F-driven gene expression and inhibits CDK1 and CDK3 T-loop phosphorylation.

Specifications

Chemical Name or Material N-[(1 S)-2-(Dimethylamino)-1-phenylethyl]-4,6-dihydro-6,6-dimethyl-3-[[4-[(1-oxo-2-propen-1-yl)amino]benzoyl]amino]pyrrolo[3,4-c]pyrazole-5(1 H)-carboxamide
CAS 1957203-01-8
Quantity 5 mg
Target Cyclin-dependent Kinase Inhibitors
Molecular Formula C28H33N7O3
Purity 0.95
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