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Tocris Bioscience™ YM 26734

Secretory phospholipase A2 (sPLA2) inhibitor

Manufacturer:  Tocris Bioscience™ 2522/10

Catalog No. 25-221-0

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Competitive inhibitor of secretory phospholipase A 2 (sPLA 2 ) that exhibits a broad inhibitory profile to several sPLA 2 s (IC 50 values are 0.2, 1, 1, 1 and 3 µM for sPLA 2 -X, -IIA, -IID, -V and -IIE respectively). Displays minimal activity at sPLA 2 -IIF and no activity at cytosolic PLA 2 cyclooxygenase and lipoxygenase. Ameliorates local inflammatory responses in TPA-induced mouse ear edema.


YM 26734
YM 26734
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