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Invitrogen™ YTHDF2 Polyclonal Antibody
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Catalog No. FEPA5144639
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FEPA5144639 100 μL
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Catalog No. FEPA5144639 Supplier Invitrogen™ Supplier No. PA5144639
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Description

Rabbit Polyclonal Antibody

Positive control: 293T cell lysate, PC-12 cell lysate, NIH/3T3 cell lysates, NIH/3T3. Predicted band size: 62 kDa Subcellular Location: Nucleus, cytosol.

Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability. Acts as a regulator of mRNA stability: binding to m6A-containing mRNAs results in the localization to mRNA decay sites, such as processing bodies (P-bodies), leading to mRNA degradation. Also acts as a promoter of cap-independent mRNA translation following heat shock stress: upon stress, relocalizes to the nucleus and specifically binds mRNAs with some m6A methylation mark at their 5'-UTR, protecting demethylation of mRNAs by FTO, thereby promoting cap-independent mRNA translation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen YTHDF2
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
Gene YTHDF2
Gene Accession No. Q91YT7, Q9Y5A9
Gene Alias 9430020E02Rik; CAHL; CLL-associated antigen KW-14; HGRG8; high glucose-regulated protein 8; high-glucose-regulated protein 8; LOW QUALITY PROTEIN: YTH domain-containing family protein 2; NY-REN-2; renal carcinoma antigen NY-REN-2; YTH domain family 2; YTH domain family protein 2; YTH domain family, member 2; YTH domain-containing family protein 2; YTH N(6)-methyladenosine RNA binding protein 2; YTH N6-methyladenosine RNA binding protein 2; yth2; YTHDF2; zgc:56224
Gene Symbols YTHDF2
Host Species Rabbit
Immunogen Recombinant protein within Full length of Human YTHDF2.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 213541, 313053, 51441
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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