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  5. Tocris Bioscience™ (Z)-4-Hydroxytamoxifen

Tocris Bioscience™ (Z)-4-Hydroxytamoxifen
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Catalog No. 341210
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34-1210 10 mg
34-125-0 50 mg
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Catalog No. 34-1210 Supplier Tocris Bioscience™ Supplier No. 3412/10
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Description

Metabolite of tamoxifen (Cat. No. 0999)

(Z)-4-Hydroxytamoxifen is an estrogen receptor antagonist (IC50 = 27 μM). (Z)-4-Hydroxytamoxifen is a Tamoxifen (Cat. No. 0999) metabolite; that exhibits greater potency than the parent compound. (Z)-4-Hydroxytamoxifen Also activates intein-linked inactive Cas9, reducing off-target CRISPR-mediated gene editing; system has ∽25-fold higher specificity than wtCas9. (Z)-4-Hydroxytamoxifen binds to voltage-gated sodium channels, near the intracellular gate and inhibits the sodium current by delaying channel recovery from the inactivated state (IC50 values are 297 nM and 2.1 μM for NavM and human Nav, respectively in HEK cells); this inhibition is independent of estrogen receptor modulation. Chemotherapeutic agent.

Chemical Identifiers

CAS 68047-06-3
Molecular Formula C26H29NO2

Specifications

Quantity 10 mg
Formula Weight 387.51
Purity >98%
Molecular Weight (g/mol) 387.523
Chemical Name or Material (Z)-4-Hydroxytamoxifen

Safety and Handling

Recommended Storage Store at +4°C
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