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Invitrogen™ ZAK Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA549885

Catalog No. PA549885


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Description

Description

The antibody detects endogenous levels of total ZAK protein.

ZAK is a leucine zipper-containing mitogen-activated protein related to the MLKs in both sequence and function. Like the MLKs and other MAP3Ks, ZAK activates MAP2Ks. ZAK is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif. This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

ZAK
Polyclonal
Unconjugated
MAP3K20
AV006891; AZK; B230120H23Rik; HCCS4; HCCS-4; Human cervical cancer suppressor gene 4 protein; leucine zipper- and sterile alpha motif kinase ZAK; Leucine zipper- and sterile alpha motif-containing kinase; Map3k20; Mitogen-activated protein kinase kinase kinase 20; Mitogen-activated protein kinase kinase kinase MLT; mixed lineage kinase 7; mixed lineage kinase with a leucine zipper and a sterile alpha motif; mixed lineage kinase-related kinase; mixed lineage kinase-related kinase MRK-beta; MLK7; mlklak; MLK-like mitogen-activated protein triple kinase; MLK-related kinase; MLT; MLTK; MLTKalpha; MLTKbeta; MRK; pk; RGD1561394; SFMMP; sterile alpha motif and leucine zipper containing kinase AZK; sterile alpha motif- and leucine zipper-containing kinase AZK; sterile-alpha motif and leucine zipper containing kinase AZK; ZAK
Rabbit
Antigen affinity chromatography
RUO
51776, 65964
-20°C
Liquid
Western Blot, Immunocytochemistry
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Q9ESL4, Q9NYL2
MAP3K20
Synthesized peptide derived from C-terminal of human MLTK.
100 μL
Primary
Human, Mouse
Antibody
IgG
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