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ZAP70 Mouse anti-Human, Clone: SPM362, Abnova™

Mouse monoclonal antibody raised against partial recombinant human ZAP70.

Manufacturer:  Abnova Corporation MAB13176

Catalog No. 89-935-122


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Description

Description

This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq]

Specifications

Specifications

ZAP70
SPM362
Mouse monoclonal antibody raised against partial recombinant human ZAP70.
In 1mM PBS.
FLJ17670/FLJ17679/SRK/STD/TZK/ZAP-70
Mouse
IgG2a, kappa
100 ug
Store at -20 to -80°C.
Aliquot to avoid repeated freezing and thawing.
Monoclonal
Human
Flow Cytometry, Immunofluorescence, Immunohistochemistry (PFA fixed)
Unconjugated
Flow Cytometry (0.5-1 ug/106 cells in 0.1 mL) Immunofluorescence (0.5-1 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL) The optimal working dilution should be determined by the end user.
Liquid
ZAP70
Recombinant protein corresponding to amino acids 1-254 and encompassing SH2 domain of human ZAP70.
Protein A/G purification
RUO
Primary
7535
SDS
Documents
Product Certifications
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