ZAP70 Mouse anti-Human, Clone: SPM362, Abnova™

Catalog No.	Quantity
89-935-122	100 μg

Catalog No. 89-935-122 Supplier Abnova Corporation Supplier No. MAB13176

Description

Mouse monoclonal antibody raised against partial recombinant human ZAP70.

This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq]

Specifications

• Antigen: ZAP70
• Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (PFA fixed)
• Classification: Monoclonal
• Clone: SPM362
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against partial recombinant human ZAP70.
• Dilution: Flow Cytometry (0.5-1 ug/10⁶ cells in 0.1 mL) Immunofluorescence (0.5-1 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL) The optimal working dilution should be determined by the end user.
• Formulation: In 1mM PBS.
• Gene Alias: FLJ17670/FLJ17679/SRK/STD/TZK/ZAP-70
• Gene Symbols: ZAP70
• Host Species: Mouse
• Immunogen: Recombinant protein corresponding to amino acids 1-254 and encompassing SH2 domain of human ZAP70.
• Purification Method: Protein A/G purification
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 7535
• Target Species: Human
• Content And Storage: Store at -20 to -80°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid
• Isotype: IgG2a κ