ZAP70 Mouse anti-Human, Clone: SPM362, Abnova™

Mouse monoclonal antibody raised against partial recombinant human ZAP70.

Supplier:  Abnova Corporation MAB13176

Catalog No. 89-935-122

Description

This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq]

Specifications

• Antigen: ZAP70
• Classification: Monoclonal
• Conjugate: Unconjugated
• Dilution: Flow Cytometry (0.5-1 ug/10⁶ cells in 0.1 mL) Immunofluorescence (0.5-1 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL) The optimal working dilution should be determined by the end user.
• Gene Alias: FLJ17670/FLJ17679/SRK/STD/TZK/ZAP-70
• Host Species: Mouse
• Purification Method: Protein A/G purification
• Regulatory Status: RUO
• Gene ID (Entrez): 7535
• Content And Storage: Store at -20 to -80°C.
  Aliquot to avoid repeated freezing and thawing.
• Isotype: IgG2a κ

• Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (PFA fixed)
• Clone: SPM362
• Description: Mouse monoclonal antibody raised against partial recombinant human ZAP70.
• Formulation: In 1mM PBS.
• Gene Symbols: ZAP70
• Immunogen: Recombinant protein corresponding to amino acids 1-254 and encompassing SH2 domain of human ZAP70.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Form: Liquid