ZBED1 Monoclonal Antibody (OTI2H3), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA505045

Catalog No. 50-167-5600

Description

ZBED1, also known as DREF, is the human homolog of the Drosophila protein DREF, a transcriptional regulatory factor required for expression of genes involved in DNA replication and cell proliferation. RNA interference (RNAi) experiments targeting ZBED1 RNA resulted in the inhibition of S phase entry and reduction of histone H1 mRNA in HeLa cells, suggesting that ZBED1 also plays a role in cell proliferation in human cells. At least 22 ribosomal proteins (RPs) possess ZBED1 binding sites in their promoters; anti-ZBED1 RNAi also resulted in decreased RP gene expression. Immunoprecipitation analyses have shown that ZBED1 self-associates in vivo via a carboxyl-terminal hATC domain, and this self-association is required for nuclear localization and DNA binding.

Specifications

• Antigen: ZBED1
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: O96006
• Gene Symbols: ZBED1
• Immunogen: Full length human recombit protein of human ZBED1 produced in HEK293T cell.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Flow Cytometry, Western Blot
• Clone: OTI2H3
• Conjugate: Unconjugated
• Gene: ZBED1
• Gene Alias: ALTE, DREF, TRAMP, hDREF
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 9189
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid