ZBED1 Mouse anti-Human, Clone: OTI1F2, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF505039

Catalog No. 50-166-3335

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

ZBED1, also known as DREF, is the human homolog of the Drosophila protein DREF, a transcriptional regulatory factor required for expression of genes involved in DNA replication and cell proliferation. RNA interference (RNAi) experiments targeting ZBED1 RNA resulted in the inhibition of S phase entry and reduction of histone H1 mRNA in HeLa cells, suggesting that ZBED1 also plays a role in cell proliferation in human cells. At least 22 ribosomal proteins (RPs) possess ZBED1 binding sites in their promoters; anti-ZBED1 RNAi also resulted in decreased RP gene expression. Immunoprecipitation analyses have shown that ZBED1 self-associates in vivo via a carboxyl-terminal hATC domain, and this self-association is required for nuclear localization and DNA binding.

Specifications

• Antigen: ZBED1
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: ZBED1
• Gene Alias: ALTE, DREF, TRAMP, hDREF
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 9189
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Western Blot
• Clone: OTI1F2
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: O96006
• Gene Symbols: ZBED1
• Immunogen: Full length human recombit protein of human ZBED1 produced in HEK293T cell.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1