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Invitrogen™ ZBP1 Polyclonal Antibody
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Catalog No. PIPA559495
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100 μL
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PIPA559495 100 μL
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Catalog No. PIPA559495 Supplier Invitrogen™ Supplier No. PA559495
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: GHGNIITRQT VSREDGSAGP RHLPSMAPGD SSTWGTLVDP WGPQDIHMER SILRRVQLGH SNEMRLHGVP SEGPAHIPPG SPPVSATAAG PEASFEARIP SPG Highest antigen sequence identity to the following orthologs: Mouse - 40%, Rat - 44%.

Z-DNA binding protein 1 (ZBP1) belongs to a family of proteins that contain the Zalpha domain which binds specifically to left-handed Z-DNA and Z-RNA. ZBP1 was initially identified as a novel gene that was up-regulated in activated macrophages in mice bearing ascites tumors, suggesting that is may play a role in processes such as host response in neoplasia. More recent reports indicate that the cytosolic ZBP1 has can act like the toll-like receptor TLR9 by detecting cytosolic double-stranded (ds) DNA and trigger induction of type I interferon and other innate immune responses. It is thought that the binding of ZBP1 to dsDNA enhances its association with innate immune response proteins such as the IRF3 transcription factor and the serine/threonine kinase TBK1 (also known as NAK). Multiple isoforms of ZBP1 are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ZBP1
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene ZBP1
Gene Accession No. Q9H171
Gene Alias 2010010H03Rik; C20orf183; Dai; Dlm1; DLM-1; DNA-dependent activator of IFN-regulatory factors; DNA-dependent activator of IRFs; mZaDLM; RP4-718J7.1; Tumor stroma and activated macrophage protein DLM-1; Zbp1; Z-DNA binding protein 1; Z-DNA-binding protein 1
Gene Symbols ZBP1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human ZBP1. Recombinant protein control fragment (Product #RP-99403).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 81030
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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