Invitrogen™ ZBTB2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA523440

Catalog No. PIPA523440

Description

The amino acid sequence used as immunogen for this antibody is 88% homologous in Equine and Bovine.

ZBTB2 is a transcription factor gene that belongs to the BTB/POZ zinc-finger family, characterized by a BTB/POZ domain at the N-terminus and multiple zinc-finger domains at the C-terminus. This gene is known for its role in regulating gene expression, particularly in the repression of genes like ARF, p53, and p21, and it functions as both a repressor and activator. ZBTB2 interacts with a variety of proteins involved in complex biological processes such as RNA processing, transcription regulation, and DNA packaging. Its zinc-finger domains predominantly belong to C2H2 and PHD types. ZBTB2 is involved in nucleosome remodeling through its interaction with chromatin modifiers and histone chaperones during developmental cell state transitions. The gene has been implicated in human cancers, where it functions as an oncogene, particularly in gastric cancers, and plays a role in the development of chronic myeloid leukemia. ZBTB2's localization at promoter regions is noted for colocalizing with several other chromatin-modifying proteins like EP400, KAT5, MBD3, and CHD4, indicating its significant role in chromatin dynamics.

Specifications

• Antigen: ZBTB2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ZBTB2
• Gene Alias: Gm1103; KIAA1483; Zbtb2; zinc finger and BTB domain containing 2; zinc finger and BTB domain-containing protein 2; ZNF437; ZNF909
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 100060294, 308126, 381990, 484036, 57621
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 0.05% BSA and 0.05% sodium azide
• Gene Accession No.: Q8N680
• Gene Symbols: ZBTB2
• Immunogen: A portion of amino acids 450 to 500 of human ZBTB2.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat, Canine, Monkey, Horse, Marsupial
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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