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Invitrogen™ ZBTB2 Polyclonal Antibody
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Catalog No. PIPA582836
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PIPA582836 100 μL
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Catalog No. PIPA582836 Supplier Invitrogen™ Supplier No. PA582836
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: DTYTMVDKQT LELCTFEEGS QMDNMLVQTN KPYKCNLCDK TFSTPNEVVK HSCQNQNSDV FALDEGRSIL LGSGDSEVTE PDHPVLASIK Highest antigen sequence indentity to the following orthologs: Rat - 96%, Mouse - 98%.

ZBTB2 is a transcription factor gene that belongs to the BTB/POZ zinc-finger family, characterized by a BTB/POZ domain at the N-terminus and multiple zinc-finger domains at the C-terminus. This gene is known for its role in regulating gene expression, particularly in the repression of genes like ARF, p53, and p21, and it functions as both a repressor and activator. ZBTB2 interacts with a variety of proteins involved in complex biological processes such as RNA processing, transcription regulation, and DNA packaging. Its zinc-finger domains predominantly belong to C2H2 and PHD types. ZBTB2 is involved in nucleosome remodeling through its interaction with chromatin modifiers and histone chaperones during developmental cell state transitions. The gene has been implicated in human cancers, where it functions as an oncogene, particularly in gastric cancers, and plays a role in the development of chronic myeloid leukemia. ZBTB2's localization at promoter regions is noted for colocalizing with several other chromatin-modifying proteins like EP400, KAT5, MBD3, and CHD4, indicating its significant role in chromatin dynamics.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ZBTB2
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene ZBTB2
Gene Accession No. Q8N680
Gene Alias Gm1103; KIAA1483; Zbtb2; zinc finger and BTB domain containing 2; zinc finger and BTB domain-containing protein 2; ZNF437; ZNF909
Gene Symbols ZBTB2
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human ZBTB2. Recombinant protein control fragment (Product #RP-93659).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 57621
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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