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Invitrogen™ ZBTB4 Monoclonal Antibody (OTI1F6)
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Catalog No. PIMA527452
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100 μL
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Catalog No. Quantity
PIMA527452 100 μL
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Catalog No. PIMA527452 Supplier Invitrogen™ Supplier No. MA527452
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Description

Mouse Monoclonal Antibody

ZBTB4 Monoclonal Antibody for Western Blot, IHC (P)

The ZBTB family of proteins is comprised of diverse zinc finger proteins that also contain a BTB (BR-C, ttk and bab) domain. Similar to Kaiso, a zinc-finger containing protein that can bind methylated CpGs, ZBTB4 can also bind methylated DNA and repress transcription. ZBTB4 has been shown to associate with the Sin3/histone deacetylase co-repressor and repress expression of P21CIP1 as part of a heterodimeric complex with Miz1. In cultured cells, depletion of ZBTB4 promotes cell cycle arrest in response to p53 activation and suppresses apoptosis through regulation of P21CIP1, suggesting that ZBTB4 is a critical determinant of the cellular response to p53 activation. HIPK2, a kinase that is involved in cellular proliferation and survival, phosphorylates and down-regulates ZBTB4 under normal cell growth conditions; this degradation increases with DNA damage.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ZBTB4
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone OTI1F6
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene ZBTB4
Gene Accession No. Q9P1Z0
Gene Alias 2310026P19Rik; 9230111I22Rik; KAISO-L1; KAISO-like zinc finger protein 1; Kiaa1538; mKIAA1538; Zbtb4; zinc finger and BTB domain containing 4; zinc finger and BTB domain-containing protein 4; ZNF903
Gene Symbols ZBTB4
Host Species Mouse
Immunogen Human recombinant protein fragment corresponding to amino acids 788-1013 of ZBTB4 produced in E.coli.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 57659
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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