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Invitrogen™ ZBTB4 Polyclonal Antibody
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Catalog No. PIPA521084
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100 μg
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Catalog No. Quantity
PIPA521084 100 μg
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Catalog No. PIPA521084 Supplier Invitrogen™ Supplier No. PA521084
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Description

Rabbit Polyclonal Antibody

A suggested positive control is SK-N-SH cell lysate. PA5-21084 can be used with blocking peptide PEP-1198.

The ZBTB family of proteins is comprised of diverse zinc finger proteins that also contain a BTB (BR-C, ttk and bab) domain. Similar to Kaiso, a zinc-finger containing protein that can bind methylated CpGs, ZBTB4 can also bind methylated DNA and repress transcription. ZBTB4 has been shown to associate with the Sin3/histone deacetylase co-repressor and repress expression of P21CIP1 as part of a heterodimeric complex with Miz1. In cultured cells, depletion of ZBTB4 promotes cell cycle arrest in response to p53 activation and suppresses apoptosis through regulation of P21CIP1, suggesting that ZBTB4 is a critical determinant of the cellular response to p53 activation. HIPK2, a kinase that is involved in cellular proliferation and survival, phosphorylates and down-regulates ZBTB4 under normal cell growth conditions; this degradation increases with DNA damage.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ZBTB4
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene ZBTB4
Gene Accession No. Q5F293, Q9P1Z0
Gene Alias 2310026P19Rik; 9230111I22Rik; KAISO-L1; KAISO-like zinc finger protein 1; Kiaa1538; mKIAA1538; Zbtb4; zinc finger and BTB domain containing 4; zinc finger and BTB domain-containing protein 4; ZNF903
Gene Symbols ZBTB4
Host Species Rabbit
Immunogen An 18 amino acid peptide near the carboxy terminus of human ZBTB4.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 57659, 75580
Target Species Human, Mouse
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG
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