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Invitrogen™ ZBTB4 Polyclonal Antibody
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Catalog No. PIPA564181
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100 μL
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PIPA564181 100 μL
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Catalog No. PIPA564181 Supplier Invitrogen™ Supplier No. PA564181
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: TPTPVIAYSK GSAGTRPGDV KEEAPQEMQV SSSSGEAGGG STAAEEASET ASLQDPIISG GEEPPVVASG GSYVYPPV Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 86%.

The ZBTB family of proteins is comprised of diverse zinc finger proteins that also contain a BTB (BR-C, ttk and bab) domain. Similar to Kaiso, a zinc-finger containing protein that can bind methylated CpGs, ZBTB4 can also bind methylated DNA and repress transcription. ZBTB4 has been shown to associate with the Sin3/histone deacetylase co-repressor and repress expression of P21CIP1 as part of a heterodimeric complex with Miz1. In cultured cells, depletion of ZBTB4 promotes cell cycle arrest in response to p53 activation and suppresses apoptosis through regulation of P21CIP1, suggesting that ZBTB4 is a critical determinant of the cellular response to p53 activation. HIPK2, a kinase that is involved in cellular proliferation and survival, phosphorylates and down-regulates ZBTB4 under normal cell growth conditions; this degradation increases with DNA damage.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ZBTB4
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene ZBTB4
Gene Accession No. Q9P1Z0
Gene Alias 2310026P19Rik; 9230111I22Rik; KAISO-L1; KAISO-like zinc finger protein 1; Kiaa1538; mKIAA1538; Zbtb4; zinc finger and BTB domain containing 4; zinc finger and BTB domain-containing protein 4; ZNF903
Gene Symbols ZBTB4
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human ZBTB4. Recombinant protein control fragment (Product #RP-103705).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 57659
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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