Invitrogen™ ZBTB4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA564181

Catalog No. PIPA564181

Description

Immunogen sequence: TPTPVIAYSK GSAGTRPGDV KEEAPQEMQV SSSSGEAGGG STAAEEASET ASLQDPIISG GEEPPVVASG GSYVYPPV Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 86%.

The ZBTB family of proteins is comprised of diverse zinc finger proteins that also contain a BTB (BR-C, ttk and bab) domain. Similar to Kaiso, a zinc-finger containing protein that can bind methylated CpGs, ZBTB4 can also bind methylated DNA and repress transcription. ZBTB4 has been shown to associate with the Sin3/histone deacetylase co-repressor and repress expression of P21CIP1 as part of a heterodimeric complex with Miz1. In cultured cells, depletion of ZBTB4 promotes cell cycle arrest in response to p53 activation and suppresses apoptosis through regulation of P21CIP1, suggesting that ZBTB4 is a critical determinant of the cellular response to p53 activation. HIPK2, a kinase that is involved in cellular proliferation and survival, phosphorylates and down-regulates ZBTB4 under normal cell growth conditions; this degradation increases with DNA damage.

Specifications

• Antigen: ZBTB4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ZBTB4
• Gene Alias: 2310026P19Rik; 9230111I22Rik; KAISO-L1; KAISO-like zinc finger protein 1; Kiaa1538; mKIAA1538; Zbtb4; zinc finger and BTB domain containing 4; zinc finger and BTB domain-containing protein 4; ZNF903
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 57659
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9P1Z0
• Gene Symbols: ZBTB4
• Immunogen: Recombinant protein corresponding to Human ZBTB4. Recombinant protein control fragment (Product #RP-103705).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG