ZBTB4/ZNF903 Rabbit anti-Human, Polyclonal, Bioss

Catalog No.	Quantity
50-198-2990	100 μL

Catalog No. 50-198-2990 Supplier Bioss Supplier No. BS13574R

Description

Rabbit Polyclonal Antibody

The ZBTB family of proteins is comprised of diverse zinc finger proteins that also contain a BTB (BR-C, ttk and bab) domain. Similar to Kaiso, a zinc-finger containing protein that can bind methylated CpGs, ZBTB4 can also bind methylated DNA and repress transcription. ZBTB4 has been shown to associate with the Sin3/histone deacetylase co-repressor and repress expression of P21CIP1 as part of a heterodimeric complex with Miz1. In cultured cells, depletion of ZBTB4 promotes cell cycle arrest in response to p53 activation and suppresses apoptosis through regulation of P21CIP1, suggesting that ZBTB4 is a critical determinant of the cellular response to p53 activation. HIPK2, a kinase that is involved in cellular proliferation and survival, phosphorylates and down-regulates ZBTB4 under normal cell growth conditions; this degradation increases with DNA damage.

Specifications

• Antigen: ZBTB4/ZNF903
• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene: ZBTB4
• Gene Accession No.: Q9P1Z0
• Gene Alias: 2310026P19Rik; 9230111I22Rik; KAISO-L1; KAISO-like zinc finger protein 1; KIAA1538; mKIAA1538; Zbtb4; zinc finger and BTB domain containing 4; Zinc finger and BTB domain-containing protein 4; ZNF903
• Gene Symbols: ZBTB4
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide derived from human ZBTB4/ZNF903.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 57659
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG