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Invitrogen™ ZBTB5 Polyclonal Antibody
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Catalog No. PIPA554437
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100 μL
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PIPA554437 100 μL
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Catalog No. PIPA554437 Supplier Invitrogen™ Supplier No. PA554437
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: GEKEHMRVVV KSEPLSSPEP QDEVSDVTSQ AEGSESVEVE GVVVSAEKID LSPESSDRSF SDPQSSTDRV GDIHILEVTN NLEHKSTFSI SNFLNKSRGN NFTANQNN Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 93%.

The ZBTB family of proteins is comprised of diverse zinc finger proteins that also contain a BTB (BR-C, ttk and bab) domain. ZBTB5 was identified though sequence analysis as a POZ domain Kruppel-like zinc finger (POK) protein. Further experiments indicated that it binds DNA and can directly repress transcription of the cell cycle arrest gene p21. ZBTB5 can also interact with co-repressor histone deacetylase complexes such as BCoR, NCoR, and SMRT via its POZ domain, resulting in deacetylation of histones Ac-H3 and Ac-H4 at the proximal promoter. ZBTB5 stimulates both cell proliferation and cell cycle progression, suggesting that it may act as a potential proto-oncogene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ZBTB5
Applications ChIP Assay, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.3 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene ZBTB5
Gene Accession No. O15062
Gene Alias 5930421I10; 9430083K24Rik; AI646847; expressed in brain and neural tube; Kiaa0354; mKIAA0354; RP11-397D12.5; Transcription factor ZNF-POZ; ZBTB5; zinc finger and BTB domain containing 5; zinc finger and BTB domain-containing protein 5
Gene Symbols ZBTB5
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human ZBTB5. Recombinant protein control fragment (Product #RP-93042).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9925
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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