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  6. BD Horizon™ Zbtb7b Rat, anti-Mouse, RY586, Clone: T43-94, BD Horizon™

BD Horizon™ Zbtb7b Rat, anti-Mouse, RY586, Clone: T43-94, BD Horizon™

Catalog No. BDB568128 Shop All BD Biosciences Products
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Catalog No. BDB568128 Supplier BD Horizon™ Supplier No. 568128
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Description

Rat Monoclonal Antibody

The T43-94 monoclonal antibody specifically recognizes mouse Zinc finger and BTB domain-containing protein 7B (Zbtb7b) which is also known as, T-helper-inducing POZ/Krueppel-like factor (Th-POK), Krueppel-related zinc finger protein cKrox (cKrox), or Zinc finger protein 67 (Zfp67). Zbtb7b is a Zn2+ finger-containing transcription factor that acts as a transcriptional repressor or activator in a promoter-dependent manner. Zbtb7b plays a role in thymic selection of T cells and is expressed in CD4+CD8+ thymocytes and mature CD4+CD8- thymocytes and T cells. It is not expressed by mature CD4-CD8+ thymocytes and T cells. It indirectly increases the expression of CD4 in developing T cells by antagonizing Runx-3-mediated CD4 repression. Zbtb7b expression has also been found in NKT and gamma/delta T cells. Zbtb7b plays a role in transcriptional repression of collagen gene expression as well.

TRUSTED_SUSTAINABILITY

Specifications

Antigen Zbtb7b
Applications Flow Cytometry
Clone T43-94
Conjugate RY586
Host Species Rat
Quantity 100 Tests
Regulatory Status RUO
Primary or Secondary Primary
Target Species Mouse
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