Invitrogen™ ZC3H13 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA561595

Catalog No. PIPA561595

Description

Immunogen sequence: DSDAYNSGDD KNEKHRLLSQ VVRPQESRSL SPSHLTEDRQ GRWKEEDRKP ERKESSRRYE EQELKEKVSS VDKQREQTEI LESSRMRAQD IIGHHQSEDR ETSDRAHDEN KKKAK Highest antigen sequence identity to the following orthologs: Mouse - 81%, Rat - 79%.

The zinc finger CCCH domain-containing protein 13 (ZC3H13) is a 1668 amino acid protein that contains one C3H1-type zinc finger. ZC3H13 is phosphorylated upon DNA damage, most likely by ATM or ATR. Two isoforms of ZC3H13 exists as a result of alternative splicing events. The gene encoding ZC3H13 maps to chromosome 13, which contains around 114 million base pairs and 400 genes. Key tumor suppressor genes on chromosome 13 include the breast cancer susceptibility gene, BRCA2, and the RB1 (retinoblastoma) gene. As with most chromosomes, polysomy of part or all of chromosome 13 is deleterious to development and decreases the odds of survival. Trisomy 13, also known as Patau syndrome, is quite deadly and the few who survive past one year suffer from permanent neurologic defects, difficulty eating and vulnerability to serious respiratory infections.

Specifications

• Antigen: ZC3H13
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ZC3H13
• Gene Alias: 2600010B19Rik; 3110050K21Rik; 4930570G11Rik; C87618; KIAA0853; RGD1307729; ZC3H13; Zinc finger CCCH domain-containing protein 13; zinc finger CCCH type containing 13; zinc finger CCCH-type containing 13
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23091
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q5T200
• Gene Symbols: ZC3H13
• Immunogen: Recombinant protein corresponding to Human ZC3H13. Recombinant protein control fragment (Product #RP-97942).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov