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Invitrogen™ ZCCHC3 Polyclonal Antibody
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Catalog No. PIPA5120538
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100 μL
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PIPA5120538 100 μL
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Catalog No. PIPA5120538 Supplier Invitrogen™ Supplier No. PA5120538
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Description

Rabbit Polyclonal Antibody

Positive test controls include: LO2, mouse liver. Immunogen sequence: SFRSAEKLAL FLRVYEEKRE QEDCWENFVV LGRSKSSLKT LFILFRNETV DVEDIVTWLK RHCDVLAVPV KVTDRFGIWT GEYKCEIELR QGEGGVRHLP GAFFLGAERG YSWYKGQPKT C.

Nucleic acid-binding protein involved in innate immune response to DNA and RNA viruses (PubMed:30193849, PubMed:30135424). Binds DNA and RNA in the cytoplasm and acts by promoting recognition of viral nucleic acids by virus sensors, such as DDX58/RIG-I, IFIH1/MDA5 and CGAS (PubMed:30193849, PubMed:30135424). Acts as a co-sensor for recognition of double-stranded DNA (dsDNA) by cGAS in the cytoplasm, thereby playing a role in innate immune response to cytosolic dsDNA and DNA virus (PubMed:30135424). Binds dsDNA and probably acts by promoting sensing of dsDNA by CGAS, leading to enhance CGAS oligomerization and activation (PubMed:30135424). Promotes sensing of viral RNA by RIG-I-like receptors proteins DDX58/RIG-I and IFIH1/MDA5 via two mechanisms: binds double-stranded RNA (dsRNA), enhancing the binding of DDX58/RIG-I and IFIH1/MDA5 to dsRNA and promotes 'Lys-63'-linked ubiquitination and subsequent activation of DDX58/RIG-I and IFIH1/MDA5 (PubMed:30193849). [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen ZCCHC3
Applications ELISA, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 2.35 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene ZCCHC3
Gene Accession No. Q9NUD5
Gene Alias C20orf99; ZCCHC3; Zinc finger CCHC domain-containing protein 3; zinc finger CCHC-type containing 3; zinc finger, CCHC domain containing 3
Gene Symbols ZCCHC3
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 215-335 of human ZCCHC3 (NP_149080.2).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 67917, 85364
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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