Invitrogen™ ZCCHC4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA557319

Catalog No. PIPA557319

Description

Immunogen sequence: FESRICQFFP SFQMLDYQVD YDNHALYKHG KTGRKQSPVR IFTNIPPNKI ILPTEEGYRF CSPCQRYVSL ENQHCEHCNS CTSKDGRKW Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 94%.

The ZCCHC4 gene encodes zinc finger CCHC domain-containing protein 4, a member of the zinc finger CCHC-type (ZCCHC) superfamily characterized by a consensus sequence C-X2-C-X4-H-X4-C. This gene plays a vital role in binding single-stranded nucleic acids, particularly RNAs, and is involved in multiple cellular processes. Notably, ZCCHC4 has been implicated in cancer, with aberrantly high expression linked to poor prognosis and chemoresistance in various cancers, including hepatocellular carcinoma, pancreatic cancer, colon cancer, and esophageal cancer. The protein exhibits RNA-modifying capabilities, influencing cell growth and survival. Recent studies have identified the structural mechanisms through which ZCCHC4 interacts with RNA substrates, offering insights into its role in regulating cancer progression and therapeutic resistance. In esophageal cancer, downregulation of ZCCHC4 may enhance sensitivity to chemotherapeutic agents like cisplatin, indicating its potential as a target for cancer treatment strategies.

Specifications

• Antigen: ZCCHC4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ZCCHC4
• Gene Alias: 4930449I23Rik; DHHC domain-containing zinc finger protein; HSPC052; rRNA N6-adenosine-methyltransferase ZCCHC4; Zcchc4; ZGRF4; zinc finger CCHC domain-containing protein 4; zinc finger CCHC-type containing 4; zinc finger, CCHC domain containing 4; zinc finger, GRF-type containing 4
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 29063
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9H5U6
• Gene Symbols: ZCCHC4
• Immunogen: Recombinant protein corresponding to Human ZCCHC4. Recombinant protein control fragment (Product #RP-102673).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov