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ZDHC3 Polyclonal Antibody, Invitrogen™

Catalog No. PIPA5112327
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PIPA5112327 100 μL
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Catalog No. PIPA5112327 Supplier Thermo Scientific Supplier No. PA5112327

Description

Rabbit Polyclonal Antibody

Golgi-localized palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates (PubMed:19001095, PubMed:21926431, PubMed:22240897, PubMed:23034182, PubMed:22314500). Plays an important role in G protein-coupled receptor signaling pathways involving GNAQ and potentially other heterotrimeric G proteins by regulating their dynamic association with the plasma membrane (PubMed:19001095). Palmitoylates ITGA6 and ITGB4, thereby regulating the alpha-6/beta-4 integrin localization, expression and function in cell adhesion to laminin (PubMed:22314500). Plays a role in the TRAIL-activated apoptotic signaling pathway most probably through the palmitoylation and localization to the plasma membrane of TNFRSF10A (PubMed:22240897). In the brain, by palmitoylating the gamma subunit GABRG2 of GABA(A) receptors and regulating their postsynaptic accumulation, plays a role in synaptic GABAergic inhibitory function and GABAergic innervation. Palmitoylates the neuronal protein GAP43 which is also involved in the formation of GABAergic synapses. Palmitoylates NCDN thereby regulating its association with endosome membranes. Probably palmitoylates PRCD and is involved in its proper localization within the photoreceptor. Could mediate the palmitoylation of NCAM1 and regulate neurite outgrowth. Could palmitoylate DNAJC5 and regulate its localization to Golgi membranes. Also constitutively palmitoylates DLG4. May also palmitoylate SNAP25. Could palmitoylate the glutamate receptors GRIA1 and GRIA2 but this has not been confirmed in vivo. Could also palmitoylate the D(2) dopamine receptor DRD2 (PubMed:26535572). [UniProt]
TRUSTED_SUSTAINABILITY

Specifications

Antigen ZDHC3
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.03% ProClin 300; pH 7
Gene ZDHHC3
Gene Accession No. Q9NYG2
Gene Alias 1110020O22Rik; 1810006O10Rik; 2210017C02Rik; DHHC1 protein; DHHC-3; GABA-A receptor-associated membrane protein 1; Godz; Golgi apparatus-specific protein with DHHC zinc finger domain; golgi-specific DHHC Zinc Finger Protein; Gramp1; HSD49; Palmitoyltransferase ZDHHC3; Protein DHHC1; Zdhhc3; Zfp373; Zinc finger DHHC domain-containing protein 3; zinc finger DHHC-type containing 3; zinc finger protein 373; zinc finger, DHHC domain containing 3; zinc finger, DHHC-type containing 3; ZNF373
Gene Symbols ZDHHC3
Host Species Rabbit
Immunogen E. coli-derived Human ZDHHC3 fragment
Purification Method Antigen affinity chromatography, Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 51304
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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