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Invitrogen™ ZEB1 Polyclonal Antibody
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Catalog No. PIPA596366
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100 μL
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PIPA596366 100 μL
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Catalog No. PIPA596366 Supplier Invitrogen™ Supplier No. PA596366
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: INIAIPTVTA QLPTIVAIAD QNSVPCLRAL AANKQTILIP QVAYTYSTTV SPAVQEPPLK VIQPNGNQDE RQDTSSEGVS NVEDQNDSDS TPPKKKMRKT E Positive Samples: SKOV3, HeLa; Cellular Location: Nucleus.

ZEB1 (Zinc finger E-box-binding homeobox 1) acts as a transcriptional repressor. It inhibits interleukin-2 (IL-2) gene expression. ZEB1 enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and depending on the cell type. It represses E-cadherin promoters and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. ZEB1 also represses BCL6 transcription in the presence of the corepressor CTBP1. It postively regulates neuronal differentiation and represses RCOR1 transcription activation during neurogenesis. Mutations in the gene can result in corneal dystrophy, posterior polymorphous and corneal dystrophy, Fuchs endothelial 6.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ZEB1
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 2.08 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.09% sodium azide; pH 7.3
Gene ZEB1
Gene Accession No. P37275, Q62947, Q64318
Gene Alias [delta]EF1; 3110032K11Rik; AREB6; BZP; Delta EF1; delta-crystallin enhancer binding factor 1; deltaEF1; DELTA-EF1; FECD6; LOW QUALITY PROTEIN: zinc finger E-box-binding homeobox 1; MEB1; MGC133261; Negative regulator of IL2; Nil2; NIL2A; NIL-2A; NIL-2-A; NIL-2-A zinc finger protein; OTTHUMP00000019405; posterior polymorphous corneal dystrophy 3; PPCD3; RP11-472N13.4; Tcf18; TCF8; TCF-8; Transcription factor 8; transcription factor 8 (represses interleukin 2 expression); Tw; twirler; ZEB; Zeb1; Zfhep; Zfhx1a; Zfx1a; Zfx1ha; zinc finger E-box binding homeobox 1; zinc finger E-box-binding homeobox 1; Zinc finger homeobox protein 1a; zinc finger homeodomain enhancer-binding protein
Gene Symbols ZEB1
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence within amino acids 800-900 of human ZEB1 (NP_1103783).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 21417, 25705, 6935
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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