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ZEB1 Polyclonal Antibody, Active Motif™
SDP

Catalog No. 501993160
Encompass
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100 μL
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50-199-3160 10 μL
50-199-3159 100 μL
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Catalog No. 50-199-3160 Supplier Active Motif Supplier No. 61120
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Description

Rabbit Polyclonal Antibody

ZEB1 (Zinc finger E-box-binding homeobox 1) acts as a transcriptional repressor. It inhibits interleukin-2 (IL-2) gene expression. ZEB1 enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and depending on the cell type. It represses E-cadherin promoters and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. ZEB1 also represses BCL6 transcription in the presence of the corepressor CTBP1. It postively regulates neuronal differentiation and represses RCOR1 transcription activation during neurogenesis. Mutations in the gene can result in corneal dystrophy, posterior polymorphous and corneal dystrophy, Fuchs endothelial 6.

Specifications

Antigen ZEB1
Applications Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration Lot-Specific
Conjugate Unconjugated
Formulation PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
Gene ZEB1
Gene Accession No. P37275
Gene Alias [delta]EF1; 3110032K11Rik; AREB6; BOS_12951; BZP; Delta EF1; delta-crystallin enhancer binding factor 1; DELTAEF1; DELTA-EF1; FECD6; MEB1; MGC133261; Negative regulator of IL2; Nil2; NIL2A; NIL-2A; NIL-2-A; NIL-2-A zinc finger protein; OTTHUMP00000019405; posterior polymorphous corneal dystrophy 3; PPCD3; RP11-472N13.4; Tcf18; Tcf8; TCF-8; Transcription factor 8; transcription factor 8 (represses interleukin 2 expression); Tw; twirler; ZEB; Zeb1; Zfhep; Zfhx1a; Zfx1a; Zfx1ha; zinc finger E-box binding homeobox 1; Zinc finger E-box-binding homeobox 1; Zinc finger homeobox protein 1a; Zinc finger homeodomain enhancer-binding protein
Gene Symbols ZEB1
Host Species Rabbit
Immunogen This ZEB1 antibody was raised against a peptide derived from the N-terminal region of human ZEB1.
Purification Method Antigen affinity chromatography
Quantity 10 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6935
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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