ZEB2 Monoclonal Antibody (OTI4D12), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA802109

Catalog No. 50-167-9113

Description

ZEB2, initially identified as Smad interacting-protein 1, is normally located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Like the homologous ZEB1, ZEB2 inhibits the transcription of the E-cadherin gene and induces epithelial-mesenchymal transition, a genetic program controlling cell migration during embryonic development and wound healing, in vitro. ZEB2 can also protect cells from DNA damage-induced apoptosis, suggesting that its expression may contribute to tumor progression. Recent evidence has shown that ZEB2 is often observed in the cytoplasm in numerous cancer tissues, indicating that its localization may be regulated in normal and tumor tissues. Mutations in this gene are also associated with Hirschsprung disease/Mowat-Wilson syndrome.

Specifications

• Antigen: ZEB2
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: O60315
• Gene Symbols: ZEB2
• Immunogen: Human recombit protein fragment corresponding to amino acids 1-350 of human ZEB2 produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Western Blot
• Clone: OTI4D12
• Conjugate: Unconjugated
• Gene: ZEB2
• Gene Alias: HSPC082, SIP-1, SIP1, SMADIP1, ZFHX1B
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 9839
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid