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Invitrogen™ ZEB2 Polyclonal Antibody
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Catalog No. PIPA582094
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100 μL
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PIPA582094 100 μL
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Catalog No. PIPA582094 Supplier Invitrogen™ Supplier No. PA582094
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: SPVKPMDSIT SPSIAELHNS VTNCDPPLRL TKPSHFTNIK PVEKLDHSRS NTPSPLNLSS TSSKNSHSSS YTPNSFSSEE LQAEPLDLSL PKQMKEPKSI IATKNKTKAS SISLDHNSVS SSSE Highest antigen sequence indentity to the following orthologs: Mouse - 94%, Rat - 95%.

ZEB2, initially identified as Smad interacting-protein 1, is normally located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Like the homologous ZEB1, ZEB2 inhibits the transcription of the E-cadherin gene and induces epithelial-mesenchymal transition, a genetic program controlling cell migration during embryonic development and wound healing, in vitro. ZEB2 can also protect cells from DNA damage-induced apoptosis, suggesting that its expression may contribute to tumor progression. Recent evidence has shown that ZEB2 is often observed in the cytoplasm in numerous cancer tissues, indicating that its localization may be regulated in normal and tumor tissues. Mutations in this gene are also associated with Hirschsprung disease/Mowat-Wilson syndrome.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ZEB2
Applications ChIP Assay, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.20 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Zeb2
Gene Accession No. O60315
Gene Alias 9130203F04Rik; D130016B08Rik; HRIHFB2411; HSPC082; KIAA0569; SIP1; SIP-1; SMAD interacting protein 1; smad-interacting protein 1; SMADIP1; Zeb2; ZFHX1B; Zfx1b; Zfxh1b; zinc finger E-box binding homeobox 2; zinc finger E-box-binding homeobox 2; zinc finger homeobox 1b; zinc finger homeobox protein 1b
Gene Symbols Zeb2
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human ZEB2. Recombinant protein control fragment (Product #RP-100743).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9839
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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